The Caspi results, reported in Science, were never neat. Children with two copies of the protective gene might suffer depression unrelated to painful events. And older studies conflicted with the new research. In Against Depression (2005), I wrote that the Science report had "raised eyebrows on a number of grounds," and I expressed doubts that the finding of absolute stress immunity would hold up.
When it came, the debunking was dramatic. In June of this year, scientists reviewing numerous studies for the Journal of the American Medical Association found no evidence that the serotonin gene offers stress protection or, indeed, any protection from depression.
Powers' book turns on the notion—now cast in doubt—that the right genes can make a person absolutely invulnerable to stress.
To be fair, some reviews have made the claim that the plausibility of the science isn't really a point in the book–that is, it just imagines a universe where this is true and goes from there.
The review also notes that the prose is bad as well:
Worse, despite the high-literary devices, Powers clings to the low-art techniques of genre fiction. Here, I should confess to a bête noire, intolerance for the method (I date it to Ian Fleming's naming of Gordon's Gin and Kina Lillet in James Bond's Vesper martini) of signaling a character's worth by cataloging his tastes in branded products
I'll also note that the review picks up on the same disregard for nuance that Wood elaborates in his piece. For a dissenting opinion, see John Domini's positive review in Bookforum, as well as Michael Orthofer's review.